False positive result in non-invasive prenatal screening (NIPS)
نویسندگان
چکیده
منابع مشابه
Improving the Positive Predictive Value of Non-Invasive Prenatal Screening (NIPS)
We evaluated performance characteristics of a laboratory-developed, non-invasive prenatal screening (NIPS) assay for fetal aneuploidies. This assay employs massively parallel shotgun sequencing with full automation. GC sequencing bias correction and statistical smoothing were performed to enhance discrimination of affected and unaffected pregnancies. Maternal plasma samples from pregnancies wit...
متن کاملP-226: Non-Invasive Prenatal Screening for Fetal Chromosomal Anomalies in South of Iran
Background: Prenatal diagnosis for Fetal Chromosomal anomalies currently relies on assessment of risk followed by a combination of biochemical and nuchal translucency. Trisomy 21 is the most common trisomy that is associated with intellectual disability. Pregnant women who receive a prenatal diagnosis of trisomy 21 currently have the option of continuing or terminating their pregnancy, but no f...
متن کاملCopy-number variation and false positive prenatal aneuploidy screening results.
Investigations of noninvasive prenatal screening for aneuploidy by analysis of circulating cell-free DNA (cfDNA) have shown high sensitivity and specificity in both high-risk and low-risk cohorts. However, the overall low incidence of aneuploidy limits the positive predictive value of these tests. Currently, the causes of false positive results are poorly understood. We investigated four pregna...
متن کاملAneuploidy screening by non‐invasive prenatal testing in twin pregnancy
OBJECTIVES To describe our experience with non-invasive prenatal testing (NIPT) in twin pregnancy. METHODS Two sets of maternal blood samples from twin pregnancies were analyzed at our laboratory using NIPT: 115 stored samples from pregnancies with known outcome (Clinical Study A) and 487 prospectively collected samples for which outcomes were requested from providers (Clinical Study B). NIPT...
متن کاملMammographic artifact leading to false-positive result
A female, 75-year-old was referred by another service with previous screening mammogram demonstrating clustered pleomorphic microcalcifications in the superolateral quadrant of her left breast, classified as highly suspicious mammographic findings (BI-RADS category 5), to be submitted to mammographyguided needle localization followed by excisional biopsy of the suspicious lesion. A new mammogra...
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ژورنال
عنوان ژورنال: Taiwanese Journal of Obstetrics and Gynecology
سال: 2018
ISSN: 1028-4559
DOI: 10.1016/j.tjog.2018.08.033